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Article

Combined RAS and SMAD4 Mutations and Microsatellite Instability Predict Outcomes in Colorectal Lung Metastases Treated with Image-Guided Thermal Ablation.

Annals of surgical oncology - 1 Jul 2026

Xu Tao, Xie Xuancheng, Gu Xinyue, Zhang Aibin, Zhang Yuye, Zhong Ziyou, Hu Jihong, Li Xinghai, Cun Jiangping, Tang Bufu, Fu Chunlong, Zeng Yulan, Wan Cheng, Xia Xiangwen, Fan Hongjie

Abstract excerpt

BACKGROUND: Image-guided thermal ablation (IGTA) is a minimally invasive alternative to colorectal cancer lung metastases (CRLM) for non-surgical candidates. This study evaluated whether combined RAS/SMAD4 mutational status and microsatellite instability (MSI) predict outcomes after IGTA in CRLM, addressing the current controversy over prognostic biomarkers. METHODS: This multicenter retrospective study analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41975044
DOI: 10.1245/s10434-026-19504-5

Genes

SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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