Article
Development of a Multiplex Amplification System Using Oxford Nanopore Sequencing for STRs and InDels.
Human mutation - 1 Jan 2026
Han Wei, Zhang Qingzhen, Zhang Xiaochang, Feng Mingjie, Xu Hao, Geng Xiaoen, Wang Yixin, Zhou Zhe
Abstract excerpt
Nanopore sequencing has emerged as a promising technology due to its real-time data acquisition, portability, and high throughput. However, the genotyping capabilities of the latest flow cell, R10.4.1, for short tandem repeats (STRs) remain insufficiently validated, and its accuracy in typing insertions or deletions (InDels) in earlier versions has been rarely investigated. To bridge these gaps, we developed the...
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