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Article

Evaluating the heterogeneous treatment effects of major depression polygenic risk scores on self-harm using causal forest.

Journal of mental health (Abingdon, England) - 1 Jun 2026

Jeong Eunji, Lee Chanhui, Kim Hyejin, Yu Hyeona, Lee Jakyung, Ha Tae Hyon, Won Hong-Hee, Myung Woojae, Kang Hyo Shin, Park Jungkyu

Abstract excerpt

BACKGROUND: Self-harm, defined as non-fatal self-inflicted harm regardless of suicidal intent, is a critical global health issue influenced by the interaction between genetic and environmental factors. AIMS: This study investigates the causal effect of major depression polygenic risk scores (MD PRS) on self-harm in individuals of European ancestry and explores how environmental and personal factors moderate this...

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Identifiers

PMID: 41969057
DOI: 10.1080/09638237.2026.2645539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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