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Article

Ex vivo effects of low dose delayed release rapamycin on agonist-induced platelet aggregation, activation and procoagulant platelet phenotypes in domestic cats.

Scientific reports - 11 Apr 2026

Shaverdian Meg, Nguyen Nghi, Fitzgerald Stuart, Grubb Louise, Stern Joshua A, Li Ronald H L

Abstract excerpt

Cardiogenic arterial thromboembolism (CATE) is a complication of cardiac diseases with a high mortality rate. Despite anti-platelet drugs use, on-treatment recurrence rate remains high indicating a critical need to discover novel therapies. Studies in both humans and cats show that low dose delayed release rapamycin (LDDRR) can reduce the progression of left ventricular hypertrophy. However, its effect on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41965408
DOI: 10.1038/s41598-026-46991-z
PMCID: PMC13221459

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