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Article

Novel JK*01 allele with c.299C>T p.(Thr100Ile) single nucleotide variant associated with loss of Jka expression in two African American donors.

Immunohematology - 1 Mar 2026

Smith Alexis, Yu Mary Vijim, Mansfield Paul, Rosa Isabella M, Keller Margaret A

Abstract excerpt

The JK blood group system encodes the antithetical antigens Jka and Jkb as well as Jk3.1 SLC14A1 on chromosome 18 spans approximately 28 kb and has 10 exons. The diallelic single nucleotide variant (SNV) c.838G>A p.(Asp280Asn) gives rise to the antithetical antigens Jka or Jkb, respectively. At the time of this publication and including this novel allele, there are 12 JK*01 alleles encoding Jk(a+w) and 29 JK*01...

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Source

Identifiers

PMID: 41965235
DOI: 10.2478/immunohematology-2026-004

Genes

SLC14A1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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