Article
Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.
Transfusion - 1 Feb 2021
Dinardo Carla L, Oliveira Theo G M, Kelly Shannon, Ashley-Koch Allison, Telen Marilyn, Schmidt Luciana C, Castilho Shirley, Melo Karla, Dezan Marcia R, Wheeler Marsha M, Johnsen Jill M, Nickerson Deborah A, Jain Deepti, Custer Brian, Pereira Alexandre C, Sabino Ester C
Abstract excerpt
BACKGROUND: Genetic variants in the SLC14A1, ACKR1, and KEL genes, which encode Kidd, Duffy, and Kell red blood cell antigens, respectively, may result in weakened expression of antigens or a null phenotype. These variants are of particular interest to individuals with sickle cell disease (SCD), who frequently undergo chronic transfusion therapy with antigen-matched units. The goal was to describe the diversity...
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