Article
Metastatic Breast Cancer to the Spine: Incidence of Somatic Gene Alterations and Association of Targeted Therapies With Overall Survival.
Neurosurgery - 1 Jun 2023
Rabah Nicholas M, Jarmula Jakub, Hamza Omar, Khan Hammad A, Chakravarthy Vikram, Habboub Ghaith, Wright James M, Steinmetz Michael P, Wright Christina H, Krishnaney Ajit A
Abstract excerpt
BACKGROUND: The increase in use of targeted systemic therapies in cancer treatments has catalyzed the importance of identifying patient- and tumor-specific somatic mutations, especially regarding metastatic disease. Mutations found to be most prevalent in patients with metastatic breast cancer include TP53, PI3K, and CDH1. OBJECTIVE: To determine the incidence of somatic mutations in patients with metastatic...
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