Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.

Circulation. Genomic and precision medicine - 1 Jun 2026

Mulder Frits I, Guman Noori A M, van Riet Job, van Geffen Roos J, van Haaps Thijs F, Hovsepjan Vahram, van Laarhoven Hanneke W M, Cirkel Geert A, de Vos Filip Y F L, Westgeest Hans M, Beerepoot Laurens V, de Vos-Geelen Judith, Labots Mariette, Hamberg Paul, Vulink Annelie J E, Los Maartje, Zwinderman Aeilko H, Robbrecht Debbie G J, de Jonge Maja J A, Büller Harry R, Kamphuisen Pieter W, Ferwerda Bart, Steeghs Neeltje, van Es Nick

Abstract excerpt

BACKGROUND: International guidelines suggest prophylactic anticoagulation for patients with cancer at high risk of venous thromboembolism (VTE). Here, we evaluated whether tumor whole-genome sequencing data may improve the selection of high-risk patients. METHODS: In a pan-cancer cohort of 3087 patients, associations of candidate clinical predictors, the germline extended 297-single nucleotide polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Risk Score

Share to Germ-Line Mutation

Share to Neoplasm Metastasis

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Venous Thromboembolism

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 41958384
DOI: 10.1161/CIRCGEN.124.005182
PMCID: PMC13263043

Genes

ELANE
PALM
POLR2E
TBX22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.PMID 41958384Read ↗

Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors.Semantic proximity Read ↗

Polygenic risk scores for prediction of cancer-associated venous thromboembolism in the UK Biobank cohort studySemantic proximity Read ↗

Genomic Profiling Identifies Somatic Mutations Predicting Thromboembolic Risk in Patients with Solid TumorsSemantic proximity Read ↗

Potential utility of comprehensive genomic profiling to predict venous thromboembolism in patients with solid cancer.Semantic proximity Read ↗

Associations of tumor somatic mutations with cancer-associated venous thromboembolism.Semantic proximity Read ↗

The role of germline and somatic mutations in predicting cancer-associated thrombosis: a narrative review.Semantic proximity Read ↗

Circulating tumor DNA predicts venous thromboembolism in patients with cancers.Semantic proximity Read ↗

Associations of tumour somatic mutations with cancer-associated venous thromboembolismSemantic proximity Read ↗

Association between tumour somatic mutations and venous thromboembolism in the 100,000 Genomes Project cancer cohort: a study protocolSemantic proximity Read ↗

Multivariable clinical-genetic risk model for predicting venous thromboembolic events in patients with cancer.Semantic proximity Read ↗

Prediction of primary venous thromboembolism based on clinical and genetic factors within the U.K. Biobank.Semantic proximity Read ↗

Association between genetic mutations and risk of venous thromboembolism in patients with solid tumor malignancies: A systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.