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Article

Obesity, physical activity, and gene-environment interactions: a natural experiment framework.

Journal of health, population, and nutrition - 9 Apr 2026

Liu Lei, Zhuang Xuxiu, Zhou Haonan, Ma Yanan, Sun Gengrun, Liu Yang, Wen Deliang

Abstract excerpt

BACKGROUND: Obesity results from the interaction of polygenic susceptibility and environmental factors. Given this complex etiology, physical activity (PA) remains a cornerstone of cost-effective intervention strategies. This longitudinal natural experiment investigated how PA modifies the effects of genetic predisposition on obesity in Chinese youth. METHODS: We conducted a 4-year natural experiment leveraging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41957874
DOI: 10.1186/s41043-026-01312-y
PMCID: PMC13262356

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LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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