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Article

Somatic mutation profiling by NGS-based liquid biopsy in advanced non-small cell lung cancer: frequency, clinical correlates, and prognostic significance.

Molecular biology reports - 23 May 2026

Doğan Çağrı, Akosman Cengiz, Sönmez Müge, Yılmaz Bahaddin, Demirağ Güzin, Abur Ümmet

Abstract excerpt

BACKGROUND: Liquid biopsy-based next-generation sequencing (NGS) of plasma cell-free DNA (cfDNA) - including its tumour-derived fraction known as circulating tumor DNA (ctDNA) - enables non-invasive, comprehensive mutational profiling in advanced non-small cell lung cancer (NSCLC). However, data on multi-gene plasma NGS panels in Turkish populations remain limited. METHODS: One hundred consecutive stage IV NSCLC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42176127
DOI: 10.1007/s11033-026-11971-z

Genes

KRAS
EGFR
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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