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Article

Measuring disease likelihood in genomic ascertainment.

American journal of human genetics - 7 May 2026

Sapp Julie C, Lewis Katie L, Modlin Emily W, Davidson Alana, Early Charlotte Linton, Buchanan Adam H, Darling Alexis, Mahder Jacquelyn, McCormick Cara Z, de Moya Allison J, Rosenblum Brooke, Similuk Morgan, Tangney Kelly, Towne Meghan C, Turner Clesson, Wilczewski Caralynn M, Johnston Jennifer J, Biesecker Leslie G

Abstract excerpt

Understanding the yield, predictive power, and utility of a secondary finding is critical for policy development and can help inform discussions for population screening. Because American College of Medical Genetics and Genomics (ACMG) Secondary Findings guidelines are applied in diverse testing contexts, we recruited participants from multiple sources to address these questions. We assessed our first 1,500...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41950923
DOI: 10.1016/j.ajhg.2026.03.009
PMCID: PMC13277679

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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