Development of a tiered and binned genetic counseling model for informed consent in the era of multiplex testing for cancer susceptibility.

doi:10.1038/gim.2014.134

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Article

Development of a tiered and binned genetic counseling model for informed consent in the era of multiplex testing for cancer susceptibility.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jun 2015

Bradbury Angela R, Patrick-Miller Linda, Long Jessica, Powers Jacquelyn, Stopfer Jill, Forman Andrea, Rybak Christina, Mattie Kristin, Brandt Amanda, Chambers Rachelle, Chung Wendy K, Churpek Jane, Daly Mary B, Digiovanni Laura, Farengo-Clark Dana, Fetzer Dominique, Ganschow Pamela, Grana Generosa, Gulden Cassandra, Hall Michael, Kohler Lynne, Maxwell Kara, Merrill Shana, Montgomery Susan, Mueller Rebecca, Nielsen Sarah, Olopade Olufunmilayo, Rainey Kimberly, Seelaus Christina, Nathanson Katherine L, Domchek Susan M

Abstract excerpt

PURPOSE: Multiplex genetic testing, including both moderate- and high-penetrance genes for cancer susceptibility, is associated with greater uncertainty than traditional testing, presenting challenges to informed consent and genetic counseling. We sought to develop a new model for informed consent and genetic counseling for four ongoing studies. METHODS: Drawing from professional guidelines, literature,...

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Identifiers

PMID: 25297947
DOI: 10.1038/gim.2014.134
PMCID: PMC4983405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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