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Article

Neurodevelopmental copy-number variants increase risk of internalizing and cardiometabolic multimorbidity: Findings from the UK Biobank.

American journal of human genetics - 4 Jun 2026

Katzourou Ioanna K, Barroso Inês, Clayton Julie, Khandaker Golam, Stow Daniel, Timpson Nicolas, Tsang Ruby, Underwood Jack, Wood Megan, Kirov George, Walters James, Owen Michael J, Holmans Peter, van den Bree Marianne B M

Abstract excerpt

Internalizing and cardiometabolic multimorbidity (ICM-MM) represents a major clinical challenge, negatively impacting life expectancy and quality of life and resulting in considerable healthcare costs. Individuals with a copy-number variant associated with increased risk of neurodevelopmental conditions (ND-CNV) are more likely to develop mental or physical ill health; however, the effects on ICM-MM remain poorly...

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Identifiers

PMID: 41946365
DOI: 10.1016/j.ajhg.2026.02.021
PMCID: PMC13277688

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