Disodium cromoglycate restricts human tau hyperphosphorylation and manifestation of associated phenotypes by inhibiting GSK3β activity in Drosophila disease models.

Abstract excerpt

BACKGROUND: Tauopathies include a group of neurodegenerative disorders characterized by the aggregation of hyperphosphorylated tau protein in brain. An imbalance between tau-specific kinases and phosphatases has been implicated in the pathogenesis of tauopathies. The glycogen synthase kinase 3β (GSK3β), a key tau kinase, has emerged as a promising therapeutic target. We evaluated whether Disodium Cromoglycate...

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