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Article

Translation control by altered start codon usage as a means of modulating the general stress response and virulence in Listeria monocytogenes.

PLoS genetics - 1 Apr 2026

Wu Jialun, Kelly Claire, Guerreiro Duarte N, Chanza Brenda, Reade Ashley, Burgess Catherine M, O'Byrne Conor

Abstract excerpt

In the food-borne pathogen Listeria monocytogenes, SigB is the central regulator of general stress response (GSR) and it mediates host entry by promoting acid resistance and epithelial cell attachment. However, mutations can readily arise to disable regulators of SigB (Rsb proteins), which suggests a considerable genetic plasticity in the GSR. To further investigate this, we defined the complete genome sequence...

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Identifiers

PMID: 41941540
DOI: 10.1371/journal.pgen.1011851
PMCID: PMC13068326

Genes

GSR

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