Article
Comparative efficacy of different therapeutic approaches in treatment naïve FLT3-mutated AML eligible for intensive chemotherapy: a Bayesian network meta-analysis of randomized trials.
Annals of hematology - 6 Apr 2026
Bruzzese Antonella, Lofaro Danilo, Martino Enrica Antonia, Mendicino Francesco, Labanca Caterina, Caserta Santino, Lucia Eugenio, Olivito Virginia, Amodio Nicola, Morabito Fortunato, Vigna Ernesto, Gentile Massimo
Abstract excerpt
FLT3-mutated acute myeloid leukemia (FLT3mut AML) is associated with poor outcomes. Although FLT3 inhibitors (FLT3is) combined with chemotherapy improve responses, long-term survival remains limited, and the optimal first-line strategy is unclear. We conducted a Bayesian network meta-analysis of eight randomized trials, including 1,793 patients, to compare treatment used in patietne eligible for intensive...
Topics
- fms-Like Tyrosine Kinase 3
- Humans
- Leukemia, Myeloid, Acute
- Randomized Controlled Trials as Topic
- Mutation
- Bayes Theorem
- Antineoplastic Combined Chemotherapy Protocols
- Phenylurea Compounds