Comparative Efficacy of Intensive Frontline Regimens in FLT3-Mutated AML: A Bayesian Network Meta-Analysis of Randomized Trials

Abstract excerpt

<title>Abstract</title> <p>FLT3-mutated acute myeloid leukemia (FLT3mut AML) is associated with poor outcomes. Although FLT3 inhibitors (FLT3is) combined with chemotherapy improve responses, long-term survival remains limited, and the optimal first-line strategy is unclear. We conducted a Bayesian network meta-analysis of eight randomized trials, including 1,793 patients, to compare intensive regimens for overall...

Topics

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• Antineoplastic Combined Chemotherapy Protocols
• Bayes Theorem
• fms-Like Tyrosine Kinase 3
• Leukemia, Myeloid, Acute
• Mutation
• Protein Kinase Inhibitors
• Staurosporine
• Treatment Outcome

Identifiers and source

Literature Corpus work

2810318f-b4f9-5de8-a48b-d9ca9f1f3fe1

DOI

10.21203/rs.3.rs-8529770/v1