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Article

Genetic variation at the MECOM locus shaping human disease pathogenesis.

Pharmacology & therapeutics - 1 Jun 2026

Chen Jiayi, Venkatesh Anirudh, Chen Kaifu, Zhang Lili

Abstract excerpt

The gene MDS1 and EVI1 complex locus (MECOM) functions as a transcriptional regulator essential for development. Variants in MECOM have been recognized as pathogenic drivers, with well-established links to oncologic and hematopoietic disorders and increasing evidence for roles in cardiovascular diseases. Here, we examine the spectrum of MECOM variants and their connections to human diseases by integrating...

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Identifiers

PMID: 41935723
DOI: 10.1016/j.pharmthera.2026.109027

Genes

MECOM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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