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Article

Unraveling the indolence of papillary thyroid carcinoma: an exploratory study on B-cell subsets based on genetic predisposition and tumor immunity.

Frontiers in immunology - 1 Jan 2026

Wang Pei, Dong Zhizhong, Peng Xing, Zhou Cong, Cheng Ruochuan, Liu Wen

Abstract excerpt

Background: Active surveillance for low-risk papillary thyroid carcinoma (PTC) is hampered by the lack of reliable biomarkers to distinguish indolent from progressive tumors. While our previous single-cell analysis identified tumor-infiltrating B cells as key determinants of indolent PTC, their clinical utility remains constrained by low abundance and peripheral undetectability. We therefore employed Mendelian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocytes, Tumor-Infiltrating

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Share to Thyroid Cancer, Papillary

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Source

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Identifiers

PMID: 41929497
DOI: 10.3389/fimmu.2026.1769020
PMCID: PMC13038570

Genes

CD27
CD38
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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