Integrating Mendelian Randomization and Epithelial Barrier Assays Reveals Protective Effects of Acetate and Histidine Against Cholesterol Depletion-Induced Esophageal Dysfunction in GERD.

Abstract excerpt

OBJECTIVE: This study aims to evaluate the causal relationship between serum biomarkers and gastroesophageal reflux disease (GERD) using Mendelian Randomization (MR) and validate key findings through in vitro functional assays. METHODS: Genome-Wide Association Study (GWAS) data for GERD were sourced from the UK Biobank and QSkin Health Study, including 71,522 GERD cases and 261,079 controls from European...

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