Article
Denosumab is associated with longer real-world progression-free survival in BRCA1/2-mutated HR+ /HER2 - breast cancer patients with bone metastases receiving CDK4/6 inhibitors: A multicenter Italian study.
European journal of cancer (Oxford, England : 1990) - 15 May 2026
Scafetta Roberta, Troiano Raffaella, Gullotta Carla, Guarino Alessandra, Fiore Cristina, Sisca Luisana, Speziale Elena, Donato Marco, Foderaro Simone, Venuti Fabio, Vilardi Francesco Antonio, Ricozzi Valentina, Iuliani Michele, Simonetti Sonia, Cavaliere Silvia, Cortellini Alessio, Cesa Annalisa La, Botticelli Andrea, Scagnoli Simone, Pisegna Simona, Criscitiello Carmen, Pedersini Rebecca, Sposetti Caterina, Tiberi Elisa, D'Auria Giuliana, Vergati Matteo, Mazzotta Marco, Caputo Roberta, Verrazzo Annarita, Garrone Ornella, Domati Federica, Piombino Claudia, Lisa Francesca Sofia Di, Filomeno Lorena, Arcuri Teresa, Puce Federica, Riva Federica, Palleschi Michela, Sirico Marianna, Piras Marta, Stucci Luigia Stefania, Lisi Delia De, Orsaria Paolo, Grasso Antonella, Ippolito Edy, Ramella Sara, Visani Luca, Livi Lorenzo, Gori Stefania, Rossi Luigi, Meattini Icro, Tagliaferri Barbara, Caffo Orazio, Bonomo Maria Vittoria, Portarena Ilaria, Irelli Azzurra, Cretella Elisabetta, Porta Camillo, Bianchini Giampaolo, Fabbri Maria Agnese, Giorgi Ugo De, Vici Patrizia, Toss Angela, Ruatta Fiorella, Laurentiis Michelino De, Villa Federica, Berardi Rossana, Minelli Mauro, Altomare Vittorio, Vernieri Claudio, Curigliano Giuseppe, Chirco Alessandra, D'Alessandro Sara, Vincenzi Bruno, Tonini Giuseppe, Santini Daniele, Pantano Francesco
Abstract excerpt
BACKGROUND: Preclinical evidence suggests that BRCA1/2-mutated tumors may rely on RANKL signaling for survival and proliferation. RANKL inhibition with denosumab could disrupt tumor-bone microenvironment crosstalk and potentially limit metastatic progression. We evaluated the association between denosumab and real-world progression-free survival (rwPFS) in germline BRCA1/2-mutated hormone...
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