Article
Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.
PloS one - 1 Jan 2022
Mesfin Eyob Abera, Merker Matthias, Beyene Dereje, Tesfaye Abreham, Shuaib Yassir Adam, Addise Desalegn, Tessema Belay, Niemann Stefan
Abstract excerpt
BACKGROUND: Ethiopia is one of the high multidrug-resistant tuberculosis (MDR-TB) burden countries. However, phenotypic drug susceptibility testing can take several weeks due to the slow growth of Mycobacterium tuberculosis complex (MTBC) strains. In this study, we assessed the performance of a Sanger sequencing approach to predict resistance against five anti-tuberculosis drugs and the pattern of resistance...
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