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Article

Method for Generation of adamtsl4 Knock-Out Zebrafish Lines Using CRRISPR/Cas9 System.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Chen Zexu, Huang Xinyi, Pi Yan, Jiang Yongxiang

Abstract excerpt

Congenital ectopia lentis (CEL) is a rare pediatric ocular disorder characterized by zonular fiber defects leading to lens dislocation and is genetically heterogeneous. Among known causes, biallelic mutations in ADAMTSL-4 represent the second most common genetic contributor, frequently associated with ectopia pupillae (EP)-a distinct and clinically significant feature. However, the mechanisms by which ADAMTSL-4...

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PMID: 41917354
DOI: 10.1007/978-1-0716-5218-3_6

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CEL

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