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Article

Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa.

International journal of molecular sciences - 25 Aug 2021

Schellens Renske, de Vrieze Erik, Graave Pam, Broekman Sanne, Nagel-Wolfrum Kerstin, Peters Theo, Kremer Hannie, Collin Rob W J, van Wijk Erwin

Abstract excerpt

Retinitis pigmentosa (RP) is an inherited retinal disease (IRD) with an overall prevalence of 1 in 4000 individuals. Mutations in EYS (Eyes shut homolog) are among the most frequent causes of non-syndromic autosomal recessively inherited RP and act via a loss-of-function mechanism. In light of the recent successes for other IRDs, we investigated the therapeutic potential of exon skipping for EYS-associated RP....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34502064
DOI: 10.3390/ijms22179154
PMCID: PMC8431288

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Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa.PMID 34502064Read ↗

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