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Article

Impact of different doses of remifentanil on postoperative pain and hyperalgesia: a prospective randomized controlled study and genotypic analysis.

Journal of clinical anesthesia - 1 Apr 2026

Xu Zixuan, Zhang Jiayi, Chen Linyao, Ye Jianwen, Wang Yanan, Tan Lei, Sun Jiehao

Abstract excerpt

BACKGROUND: Remifentanil is commonly used for perioperative analgesia, but its role in postoperative pain and hyperalgesia is still debated. This study investigated the effect of different remifentanil doses on postoperative pain and hyperalgesia and the influence of SCN9A genetic variants on these outcomes. METHODS: A total of 268 patients who underwent laparoscopic surgery were included in the study. Eligible...

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Share to Analgesics, Opioid
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41916108
DOI: 10.1016/j.jclinane.2026.112198

Genes

SCN9A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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