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Causal Relationship Between Neurotrophins and Normal Pressure Hydrocephalus: Insights From a Bidirectional Two-Sample Mendelian Randomization Study.

Brain and behavior - 1 Apr 2026

Xu Tao, Gan Qiang, Wang Handong, Liu Haifeng, Huang Xiwen

Abstract excerpt

INTRODUCTION: Researchers have postulated a link between higher levels of brain-derived neurotrophic factor (BDNF) and more favorable outcomes in patients with normal pressure hydrocephalus (NPH). However, there is no clear evidence regarding the causal association between neurotrophins and NPH. To delve deeper into this potential connection, scientists employed a rigorous method known as bidirectional Mendelian...

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Identifiers

PMID: 41913636
DOI: 10.1002/brb3.71309
PMCID: PMC13112031

Genes

CNTF
GDNF
BDNF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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