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Article

AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM2.5 exposure.

Nature communications - 30 Mar 2026

Feng Guoqing, Dong Zheng, Ke Limei, Zhou Weilai, Tian Yu, Li Xingtian, Xiang Wenxin, Li Yanjun, Huang Qi, Liu Linfeng, Yin Bo, Yan Shouyi, Liu Jianxiu, Ma Xindong, Chen Huaiyong, He Miao, Hao Ke, Liu Sijin, Di Qian

Abstract excerpt

Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncover shared transcriptional signatures between PM2.5 exposure and SARS-CoV-2 infection. We further validate this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Niemann-Pick C1 Protein

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Identifiers

PMID: 41912520
DOI: 10.1038/s41467-026-71196-3
PMCID: PMC13194984

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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