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Article

Anaplastic sarcomas of the kidney are characterized by DICER1 mutations.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2018

Wu Mona K, Vujanic Gordan M, Fahiminiya Somayyeh, Watanabe Noriko, Thorner Paul S, O'Sullivan Maureen J, Fabian Marc R, Foulkes William D

Abstract excerpt

Anaplastic sarcoma of the kidney is a rare tumor (≤25 reported cases) characterized by the presence of cysts, and solid areas composed of bundles of undifferentiated spindle cells, showing marked cellular anaplasia (usually accompanied by TP53 overexpression). These tumors often feature prominent areas of cartilage or chondroid material. Germline mutations in DICER1, encoding the microRNA (miRNA) processor...

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Source

Identifiers

PMID: 28862265
DOI: 10.1038/modpathol.2017.100

Genes

DICER1

Provenance

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