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The relationship between genomic variation and genetic load: insights from small island populations.

Heredity - 1 May 2026

Gabrielli Maëva, Benazzo Andrea, Biello Roberto, Iannucci Alessio, Salvi Daniele, Ficetola Gentile Francesco, Ciofi Claudio, Trucchi Emiliano, Bertorelle Giorgio

Abstract excerpt

Small populations face high extinction risks. This can be explained by several non-genetic and genetic factors, the latter including the loss of genetic diversity and evolutionary potential, as well as the accumulation of harmful mutations (genetic load). Using whole-genome data from island populations with different effective sizes, we estimated genetic variation and load and explored the relationship between...

Topics

Animals
Lizards
Genetic Variation
Genetics, Population
Islands
Genetic Load
Genome
Mutation
Heterozygote

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41904331
DOI: 10.1038/s41437-026-00835-8
PMCID: PMC13219662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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