Germ layer specification and organotropism in lymphoma invasion.

doi:10.1016/j.scib.2026.03.009

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Article

Germ layer specification and organotropism in lymphoma invasion.

Science bulletin - 30 Apr 2026

Dong Yan, Xu Peng-Peng, Han Xiao, Wang Yu-Qing, Chen Yi, Fang Ying, Zhu Yue, Shi Qing, Shen Rong, Shi Zi-Yang, Qiao Niu, Cheng Shu, Liu Yu, Wang Li, Zhang Mu-Chen, Zhao Wei-Li

Abstract excerpt

Relevance exists between tumorigenesis and embryonic development. Distinct clinical and molecular features, as well as the relationship between the pattern of lymphoma invasion and germ layer development remain largely unknown. We identified a germ layer-dependent specification of extranodal invasion (ENI) in diffuse large B-cell lymphoma. Upon R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and...

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