Article
Single-bacterial cell insights into mechanisms of ceftriaxone resistance in Neisseria subflava.
Nature communications - 27 Mar 2026
Zhang Xin, Cheng Hong Sheng, Zhan Xueliang, Li Xue, Huang Jiamin, Liu Haoyu, Chua Damien, Wang Guoze, Li Xingxing, Shi Yue, Wang Fuxiang, Xu Zhe, Qu Jiuxin, Pethe Kevin, Li Guobao, Tan Nguan Soon, Mac Aogáin Micheál, Chotirmall Sanjay H, Li Liang
Abstract excerpt
The contribution of airway pathobionts to chronic respiratory disease is increasingly recognized, yet the evolutionary processes that shift commensals to pathogens remain poorly understood. Here we investigate how antibiotic pressure drives adaptation in Neisseria subflava, a common airway commensal associated with bronchiectasis. Using serial passage under ceftriaxone exposure, we observe a >300-fold increase in...
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