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Article

Biomechanical Voice Parameters as Potential Biomarkers for Phenotype Differentiation in Amyotrophic Lateral Sclerosis: A Cross-Sectional Study.

Medical sciences (Basel, Switzerland) - 26 Feb 2026

Pérez-Bonilla Margarita, Mora-Ortiz Marina, Díaz-Borrego Paola, Muñoz-Alcaraz María Nieves, Mayordomo-Riera Fernando J, Girela-López Eloy

Abstract excerpt

Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease in which bulbar involvement frequently affects speech and voice production. Although acoustic voice analysis can detect phonatory alterations in ALS, its ability to differentiate clinical phenotypes remains limited. This study investigated whether biomechanical voice parameters provide complementary...

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Identifiers

PMID: 41892827
DOI: 10.3390/medsci14010112
PMCID: PMC13027408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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