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Article

Genetic nurture in intergenerational transmission of substance use.

Nature communications - 26 Mar 2026

Luo Mannan, Trindade Pons Victória, Gillespie Nathan A, van Loo Hanna M

Abstract excerpt

Substance use runs in families. Beyond genetic transmission, parental genetics can indirectly influence offspring substance use through the rearing environment, known as genetic nurture. This study utilizes transmitted and non-transmitted polygenic scores to investigate genetic nurture on tobacco, alcohol, and cannabis use in up to 15,863 adults with at least one genotyped parent from Lifelines, a...

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PMID: 41888510
DOI: 10.1038/s41467-026-71175-8
PMCID: PMC13183951

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