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Association of maternal smoking during pregnancy with youth depression and subsequent adult chronic diseases in offspring.

Translational psychiatry - 26 Mar 2026

Wei Wenming, Cheng Bolun, Qi Xin, He Dan, Cheng Shiqiang, Yang Xuena, Pan Chuyu, Meng Peilin, Hui Jingni, Gou Yifan, Zhao Boyue, Liu Li, Wen Yan, Liu Huan, Jia Yumeng, Zhang Feng

Abstract excerpt

This study aimed to elucidate the relationship between maternal smoking during pregnancy (MSDP) and the incidence of youth depression, examine the modifying role of genetic susceptibility, and assess subsequent physical health risks in adulthood. We utilized data from 60,839 participants in the UK Biobank. Cox proportional hazards models were applied to evaluate the impact of MSDP on the onset of youth...

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PMID: 41888109
DOI: 10.1038/s41398-026-03976-w
PMCID: PMC13039871

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