Comparison of clinical, pathological and genomic characteristics between Lynch and non-Lynch patients with MMRd endometrial carcinoma.

doi:10.1186/s12885-026-15826-5

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Article

Comparison of clinical, pathological and genomic characteristics between Lynch and non-Lynch patients with MMRd endometrial carcinoma.

BMC cancer - 24 Mar 2026

Mo Haixin, Zhang Weijian, Wei Jihong, Chen Jiaqing, He Jiadi, Zeng Xueqing, Liu Baoyi, Huang Jing, Ren Liangliang, Li Ronggang, Huang Xiufang, Chen Xiaoning, Liu Qiongru, Ren Dong, Pan Taijin, Qing Xingrong, Chen Yuan, Zheng Yan, Li Xiaoying, Deng Yuanyuan, Li Haicheng, Xian Danyu, Ouyang Nengtai, Zhang Xin, Zhong Qian, Ruan Xiaohong

Abstract excerpt

BACKGROUND: Lynch syndrome (LS) is a common hereditary cancer predisposition syndrome caused by pathogenic germline mutations in MMR genes. This study aimed to conduct LS screening in a South Chinese Endometrial carcinoma (EC) cohort to identify hereditary mutation profiles. METHODS: Molecular classification was performed on 201 EC patients from South China. Sixty cases were identified as MMR deficiency (MMRd)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41872806
DOI: 10.1186/s12885-026-15826-5
PMCID: PMC13134137

Genes

MLH1
MSH6
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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