The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma.

doi:10.1158/1078-0432.CCR-17-1789

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Article

The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2017

Cooke Susanna L, Ennis Darren, Evers Lisa, Dowson Suzanne, Chan Mei Yen, Paul James, Hirschowitz Lynn, Glasspool Rosalind M, Singh Naveena, Bell Sarah, Day Elizabeth, Kochman Agata, Wilkinson Nafisa, Beer Philip, Martin Sancha, Millan David, Biankin Andrew V, McNeish Iain A

Abstract excerpt

Purpose: We sought to identify the genomic abnormalities in squamous cell carcinomas (SCC) arising in ovarian mature cystic teratoma (MCT), a rare gynecological malignancy of poor prognosis.Experimental design: We performed copy number, mutational state, and zygosity analysis of 151 genes in SCC arising in MCT (n = 25) using next-generation sequencing. The presence of high-/intermediate-risk HPV genotypes was...

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PMID: 28954785
DOI: 10.1158/1078-0432.CCR-17-1789

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