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Article

Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization.

BMC medicine - 19 Mar 2026

Aiton Elisabeth, McBride Nancy S, Clayton Gemma L, Gonçalves Soares Ana, Bond Tom A, Yang Qian, Chatzigeorgiou Charikleia, West Jane, Faber Benjamin G, Birchenall Katherine, Burden Christy, Magnus Maria C, Lawlor Deborah A, Borges Maria Carolina

Abstract excerpt

BACKGROUND: Autoimmune conditions are common in women of reproductive age. They are associated with an increased risk of adverse pregnancy outcomes; whether this is causal is unclear. Our aim was to explore the causal effects of genetic liability to autoimmune conditions on pregnancy outcomes. METHODS: We conducted two-sample Mendelian randomization (MR) to estimate effects of genetic liability to ten autoimmune...

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Share to Autoimmune Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41851855
DOI: 10.1186/s12916-026-04797-w
PMCID: PMC13122933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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