Article
Evaluation of a HIV-1 drug resistance genotyping method based on high-throughput sequencing (HTS).
BMC infectious diseases - 18 Mar 2026
Li Jialu, Xu Yang, Tang Yue, Hao Jingjing, Song Chang, Mao Wansi, Li Tang, Li Xiang, Wang Dong, Lin Lu, Yang Jianwei, Wu Yuanyuan, Ruan Yuhua, Feng Yi, Wang Yicong, Xing Hui, Liao Lingjie
Abstract excerpt
BACKGROUND: High-throughput sequencing (HTS) enables the detection of low-frequency HIV-1 drug resistance mutations (DRMs) that are often missed by conventional Sanger sequencing. However, the clinical implementation of HTS remains limited, and standardized evaluations of emerging platforms are still lacking. This study aims to evaluate the performance of the MGI HTS platform in detecting HIV-1 DRMs compared to...
Topics
- HIV-1
- Humans
- Drug Resistance, Viral
- High-Throughput Nucleotide Sequencing
- HIV Infections
- Mutation
- Genotyping Techniques
- Genotype
- Anti-HIV Agents
- Viral Load