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Article

Thymic health and immunotherapy outcomes in patients with cancer.

Nature - 1 Apr 2026

Bernatz Simon, Prudente Vasco, Pai Suraj, Attermann Asbjørn K, Di Federico Alessandro, Rowan Andrew, Veeriah Selvaraju, Dyrskjøt Lars, Nürnberg Leonard, Alessi Joao V, Ott Patrick A, Sharon Elad, Hackshaw Allan, McGranahan Nicholas, Abbosh Christopher, Mak Raymond H, Bitterman Danielle, Awad Mark, Ricciuti Biagio, Swanton Charles, Jamal-Hanjani Mariam, Birkbak Nicolai J, Aerts Hugo J W L

Abstract excerpt

Although immunotherapy has revolutionized cancer treatment, many patients still experience limited benefit, highlighting the urgent need for improved biomarkers1. Although immunotherapy is founded on unleashing T cells2, most existing biomarkers remain tumour-centric and mainly overlook host immune competence. The thymus is a key immune organ that is crucial for T cell maturation, and we hypothesized that thymic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41851467
DOI: 10.1038/s41586-026-10243-x
PMCID: PMC13102699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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