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Integrative combination of gas‒liquid-phase plasma mutagenesis and high-throughput screening to enhance eicosapentaenoic acid production by Schizochytrium sp.

Journal of Zhejiang University. Science. B - 22 Dec 2025

Yu Chao, Zhu Jialin, Wu Jinyong, Chen Xiangsong, Lu Shuhuan, Li Xiangyu, Zhao Sa, Zhu Weiwei, Shu Min, Wu Mianbin, Yao Jianming

Abstract excerpt

Dietary consumption of eicosapentaenoic acid (EPA) offers diverse health benefits, such as the regulation of blood triglycerides and the prevention of cardiovascular diseases. EPA is naturally synthesized by Schizochytrium sp.; however, its low production level limits its potential for industrial application. The goal of this study was to increase EPA productivity in Schizochytrium sp. by gas‒liquid-phase plasma...

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Eicosapentaenoic Acid
Fermentation
Glucose
High-Throughput Screening Assays
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spectroscopy, Near-Infrared

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Identifiers

PMID: 41847732
DOI: 10.1631/jzus.B2400427
PMCID: PMC12996859

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