Programmable probiotic consortium employ an oleic acid-inducible system to sense and degrade cholesterol in high-fat diet mice

Abstract excerpt

High cholesterol is a major risk factor for cardiovascular disease (CVD), and current treatment strategies primarily focus on inhibiting cholesterol synthesis and reducing cholesterol absorption. Engineered synthetic consortia are emerging as a promising alternative for lowering cholesterol level and improving cardiovascular health. In this study, Escherichia coli Nissle 1917 (EcN) was engineered to express three...

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