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Development of combined mutagenesis strategy for enhanced eicosapentaenoic acid production in Schizochytrium sp.

Bioresource technology - 1 Aug 2026

Liu Kai-Xin, Chen Qing, Chen Zi-Lei, Jiang Chun-Yong, Wu Yang, Li Xiu-Juan, Liu Xiao-Le, Cao Min-Jie, Ren Bo, Yang Ya-Qiong, Guo Dong-Sheng

Abstract excerpt

Microbial production of Eicosapentaenoic acid (EPA) offers a sustainable alternative to fish oil, yet achieving high titers in Schizochytrium sp. remains challenging due to its inherent preference for docosahexaenoic acid (DHA) synthesis. In this study, a high-EPA producing mutant, Schizochytrium sp. SCNA9, was successfully isolated using a combined multi-round mutagenesis and screening strategy, with its...

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PMID: 42061578
DOI: 10.1016/j.biortech.2026.134743

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