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Article

Enhanced ganoderic acids production by using thermotolerant Ganoderma tsugae at high-temperature liquid cultivation.

PloS one - 1 Jan 2026

Ma Quan, Jing Yang-Meng-Jie, Luo Li-Yuan, He Xiao-Long, Liu Yue-Qin

Abstract excerpt

Ganoderic acids (GAs) are bioactive triterpenoids produced by Ganoderma species with demonstrated anticancer properties. While the yield of GAs in Ganoderma tsugae is typically low, heat stress has been shown to enhance its production. This study employed atmospheric and room temperature plasma (ARTP) mutagenesis to develop thermotolerant G. tsugae mutants for high-temperature cultivation at 35°C. From 59 mutants...

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Identifiers

PMID: 41843595
DOI: 10.1371/journal.pone.0345065
PMCID: PMC12994843

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