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Neurospora intermedia for single-cell protein production: Enhancement by medium optimization and atmospheric and room temperature plasma mutagenesis.

Bioresource technology - 1 Jun 2026

Zhao Haifeng, Sun Shichuang, Jin Mengru, Li Junlong, Li Mingxia, Wang Li, Zhang Wei, Wang Mengjie, Zhu Rugang, Li Tiejing, Cao Jialu, Kang Dingrong

Abstract excerpt

Neurospora intermedia can efficiently convert low-cost substrates into single-cell protein; however, systematic strategies for achieving high-density cultivation remain poorly understood. In this study, we developed a high-protein-producing mutant, T154, derived from Neurospora intermedia FF171 via atmospheric and room temperature plasma (ARTP) mutagenesis, which exhibited stable genetic traits. Medium...

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PMID: 41791606
DOI: 10.1016/j.biortech.2026.134341

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