Ascertainment Bias in Cattle SNP Arrays and Implications for Multibreed Genomic Predictions.

Abstract excerpt

Ascertainment bias of SNP for genotyping arrays, where markers are discovered largely in one breed then used to genotype other breeds, can affect scaling and dispersion of genomic breeding values in multibreed genomic evaluations. Detecting and addressing this bias is crucial for robust genetic analyses. Using whole genome sequence data, we demonstrate the extent of ascertainment bias in the most commonly used...

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