Article
Impact of different genetic mutations on granulocyte development and G-CSF responsiveness in congenital neutropenia.
Blood advances - 9 Apr 2024
Meng Xin, Zhang Hai, Dong Lulu, Min Qing, Yu Meiping, Li Yaxuan, Liu Lipin, Wang Wenjie, Ying Wenjing, Sun Jinqiao, Wang Ji-Yang, Hou Jia, Wang Xiaochuan
Abstract excerpt
ABSTRACT: Congenital neutropenia (CN) is a genetic disorder characterized by persistent or intermittent low peripheral neutrophil counts, thus increasing susceptibility to bacterial and fungal infections. Various forms of CN, caused by distinct genetic mutations, exhibit differential responses to granulocyte colony-stimulating factor (G-CSF) therapy, with the underlying mechanisms not fully understood. This study...
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