Integrated transcriptomic and variant analysis reveals molecular mechanisms of pyrethroid resistance in a genetically homogenized Cas9 strain of Aedes aegypti.

Abstract excerpt

Insecticide resistance, a central problem in insecticide toxicology, in Aedes aegypti continues to undermine vector control efforts worldwide. Although transcriptomic studies have identified numerous resistance-associated genes, differences in genetic background between resistant and susceptible strains often obscure which changes are directly linked to resistance. To reduce background variability, we generated a...

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