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Lifespan Predicts Mitochondrial Substitution Rates across Vertebrates, but Methodology Matters.

Genome biology and evolution - 2 Mar 2026

Sterling Jess E, Zwonitzer Kendra D, Havird Justin C

Abstract excerpt

Why do some species live for mere months, while others persist for centuries? A leading explanation implicates mitochondria. The mitochondrial theory of aging predicts that mitochondrial efficiency diminishes with age due to the accumulation of mutations within mitochondrial DNA (mtDNA). While experimental evidence for this theory is mixed, evolutionary analyses offer an ideal opportunity to determine if...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41837793
DOI: 10.1093/gbe/evag067
PMCID: PMC13034128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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