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Article

Aztreonam-Avibactam Resistance Due to Synergistic Interplay of ampC-Related Mutations in Carbapenem-Resistant Enterobacter spp.

The Journal of infectious diseases - 13 Mar 2026

Zeng Yang, He Yanling, Ma Ke, Feng Yu, Zong Zhiyong

Abstract excerpt

BACKGROUND: Aztreonam-avibactam (ATM-AVI) is an important antimicrobial option for metallo-β-lactamases (MBLs)-producing Enterobacterales. The ATM-AVI-resistant mechanisms remain elusive. METHODS: Through induction experiments, ATM-AVI-resistant mutants were obtained from an MBL-producing Enterobacter xiangfangensis clinical strain. Mutants were genome sequenced and analyzed. We investigated a complex combination...

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PMID: 41824649
DOI: 10.1093/infdis/jiaf384

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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