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Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.

Dialogues in clinical neuroscience - 1 Dec 2026

Bai Chyi-Huey, Fan Hsien-Yu, Lin Hui-An, Lin Sheng-Feng

Abstract excerpt

BACKGROUND: Cognitive impairment is widely reported in migraineurs. A Mendelian randomisation (MR) approach, similar to a randomised-controlled trial, employs single-nucleotide polymorphisms (SNPs) to investigate causal relationships. METHODS: This study comprised one- and two-sample MR analyses of the Taiwan Biobank. Three strategies were used to obtain causal estimates: (1) a polygenic risk score (PRS)...

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Cognitive Dysfunction
Genetic Predisposition to Disease
Genetic Risk Score
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Migraine Disorders

Polymorphism, Single Nucleotide

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PMID: 41797490
DOI: 10.1080/19585969.2026.2636459
PMCID: PMC12973854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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